Top 25 Best Vaccine-Required Colleges in the US | 2022 Rankings

The COVID-19 pandemic has made a major impact on the world, including the landscape of higher education. Many schools had to quickly change their plans and switch to online teaching or modified graduations. Though many schools are returning to in-person classes, there is one topic still buzzing: vaccine requirements.

These schools are requiring their students to be vaccinated. Schools requiring vaccination records is nothing new, but nowadays public health awareness is more important than ever.

Note: The schools on this list are vaccine-required as of August 24th, 2021 and may change their requirements in the future. 

Here are the top schools requiring their students to get the vaccine.

Top 25 Best Vaccine-Required Colleges

A private Ivy League research university, Princeton University was founded in 1746 and originally known as the College of New Jersey. This makes it the fourth-oldest institution of higher education in the country. The school receives around 32,500 applications annually and has an acceptance rate of only 5.8%, making it highly competitive.
Location Princeton, NJ
Institution Type Private
Student Enrollment 8,419
Harvard University has turned out some amazing alumni. In fact, the school has more alumni, researchers, and faculty that have won Nobel Prizes and Field Medals than any other school in the world. Alumni also include eight U.S. presidents, 188 living billionaires, and 108 Olympic medalists. The most common majors include econometrics and quantitative economics, social sciences, and computer science.
Location Cambridge, MA
Institution Type Private
Student Enrollment 31,655
The Massachusetts Institute of Technology, or MIT, currently has about 11,500 students attending. They offer up to a doctorate degree with many students focusing on computer science and mechanical engineering. Mathematics and physics are also common majors. Alumni have gone on to found companies like Intel, Koch Industries, Dropbox, and Campbell Soup.
Location Cambridge, MA
Institution Type Private
Student Enrollment 11,520
Also known as Caltech, the California Institute of Technology’s motto is, “The truth shall make you free.” Science and Engineering are top choices among students and there have been 76 Nobel laureates that have been associated with Caltech (including 40 alumni and faculty members). Just over 2,200 students attend the school today.
Location Pasadena, CA
Institution Type Private
Student Enrollment 2,237
Yale University got its start in 1701 under the name Collegiate School, getting its current name in 1718. Their motto Lux et veritas means “Light and truth” in Latin. The university is made up of fourteen schools including the undergraduate college, twelve professional schools, and the Yale Graduate School of Arts and Sciences. Students have a 6% chance of getting accepted to Yale.
Location New Haven, CT
Institution Type Private
Student Enrollment 13,609
The University of Chicago receives over 34,600 applications though only about 2,000 were accepted. Therefore, the school has a 6% acceptance rate. The school is made up of their undergraduate college and five graduate research divisions. They also have campuses all over the world from Hong Kong to Paris.
Location Chicago, IL
Institution Type Private
Student Enrollment 17,452
Stanford University has a 4% acceptance rate and a 99% first year retention rate. Their student to faculty ratio is only 5 to 1. Herbert Hoover was a graduate of Stanford and other alumni have included Fulbright Scholars, members of Congress, astronauts, and billionaires. Known as the Stanford Cardinals, their colors are cardinal and white.
Location Stanford, CA
Institution Type Private
Student Enrollment 17,249
The University of Pennsylvania was founded in 1740, primarily by Benjamin Franklin, who was also their first president. Franklin Field, where the Quakers play in the NCAA Division I – Ivy League, is named after the founder. With a 98% first year retention rate, 86% of students will go on to graduate in four years. 96% will graduate in six.
Location Philadelphia, PA
Institution Type Private
Student Enrollment 26,675
Columbia has a very low selective acceptance rate of 5.5%, accepting only about 2,300 students out of 42,900 applicants. Top choices in regards to majors include Econometrics, Computer Science, and Political Science. It’s the oldest institution of higher education in the state. Columbia is one of the nine colonial colleges founded before the Declaration of Independence.
Location New York City, NY
Institution Type Private
Student Enrollment 31,456
Methodists and Quakers founded Duke University in 1838. The school has produced 50 Rhodes Scholars, 3 Turing Award winners, and 15 Noble laureates. Known as the Blue Devils, the university’s colors are Duke blue and white. The top majors among students include Econometrics, Computer Science, Public Policy Analysis, Biology, and Nursing.
Location Durham, NC
Institution Type Private
Student Enrollment 16,686
With just under 1,600 undergraduate students, Swarthmore College is a smaller school. It was one of the first coeducational colleges in the country. The college is associated with the University of Pennsylvania through the Quaker Consortium, which means students can take classes at the four schools within the arrangement.
Location Swarthmore, PA
Institution Type Private
Student Enrollment 1,594
Edward Sorin founded the University of Notre Dame in 1842 as a private Catholic research University. Their motto is “Vita Dulcedo Spes” or “Life, Sweetness, Hope” – referencing the Virgin Mary. The school’s teams are known as the Fighting Irish, and wear the colors blue and gold. Their mascot is the very iconic leprechaun. Currently, just over 12,500 students attend.
Location Notre Dame, IN
Institution Type Private
Student Enrollment 12,683
Although it was originally founded as a men’s college in 1793, the school now has 2,150 students with about half men and half women. It was created out of the funds of Ephraim Williams, who died in the French and Indian War. The college gets just under 10,000 applications each year and accepts 13% of students.
Location Williamstown, MA
Institution Type Private
Student Enrollment 2,150
A smaller school, Pomona College has about 1,640 students. The school receives around 10,400 applications and accepts 7.4% of them. The four commonly chosen majors are Econometrics, Computer Science, Mathematics, and Neuroscience. The school was created when the founders wanted to recreate a “college of the New England type.” Their mascot is Cecil the Sagehen.
Location Claremont, CA
Institution Type Private
Student Enrollment 1,637
A selective school, fewer than 9% of applicants are accepted into Rice. The school has 11 residential colleges and eight schools of academic study. Rice University was established in 1912 and named after William Marsh Rice. He had requested a free-tuition educational institute be opened after his death. Today, about 4,000 undergraduates and 3,300 graduates attend.
Location Houston, TX
Institution Type Private
Student Enrollment 7,282
A private Ivy League research university, Dartmouth was founded before the Declaration of Independence was signed. Three famous alumni were Daniel Webster, Robert Frost, and Thaddeus Stevens. The school also graduated several members of the Senate and House of Representatives in the United States, Nobel Prize laureates, and more.
Location Hanover, NH
Institution Type Private
Student Enrollment 6,606
Top majors at Northwestern University are econometrics and quantitative economics, journalism, psychology, drama, and neuroscience. A founding member of the Big Ten Conference, top sports for the Wildcats include football, basketball, baseball, and cross country/track. Willie the Wildcat cheers them on and the colors are purple and white.
Location Evanston, IL
Institution Type Private
Student Enrollment 22,448
Washington University in St. Louis was named after George Washington and founded in 1853. A private research university, the school receives over 24,000 applications a year and accepts around 3,500 students. Commonly chosen majors are computer science, biology, and experimental psychology. Top sports on campus include track, football, and baseball.
Location St. Louis, MO
Institution Type Private
Student Enrollment 16,191
Thomas Jefferson founded The University of Virginia. The school had a Board of Visitors that included Jefferson, James Monroe, and James Madison. Well known for its secret societies, the school is also known for their sporting accomplishments. The Cavaliers, who wear orange and blue, have 21 championship wins. Over 25,000 students are currently attending.
Location Charlottesville, VA
Institution Type Public
Student Enrollment 25,012
Popular majors at Brown University include computer science, biology, entrepreneurship, and history. Founded in 1764, it was the first school in North America that accepted students regardless of their religion. Their women’s institution (Pembroke College) was merged into Brown in 1971. Alumni have gone on to create famous companies including ZipRecruiter, Cards Against Humanity, and CNN.
Location Providence, RI
Institution Type Private
Student Enrollment 10,333
With an acceptance rate of 11%, Amherst College is a fairly selective school. A majority of their first-year students come from Massachusetts, New York, and California. The third oldest institution of higher education in the state, it was originally a men’s college. It became coeducational in 1975. Amherst College’s motto is “Terras Irradient,” which means “Let them enlighten the lands.”
Location Amherst, MA
Institution Type Private
Student Enrollment 1,839
Vanderbilt University has over 13,000 students. Many students major in economics and social sciences. Other common majors are computer science, neuroscience, and mechanical engineering. The university was named in honor of Cornelius Vanderbilt, a shipping and rail magnate, due to his gift of $1 million. Their sports teams are known as the Commodores.
Location Nashville, TN
Institution Type Private
Student Enrollment 13,131
Franklin W. Olin College of Engineering was established fairly recently in 1997. Half of a student’s tuition is actually covered by the Olin Scholarship. Currently, just under 400 students attend. Majors include General Engineering, Electrical Engineering, and Mechanical Engineering. With a 99% first year retention rate, the college also has an 8 to 1 student to faculty ratio.
Location Needham, MA
Institution Type Private
Student Enrollment 386
Cornell University is made up of seven undergraduate colleges and seven graduate divisions. Some famous alumni have been Christopher Reeve, Bill Nye, E.B. White, and Anthony Fauci. 97% of students stay on after the first year, with 93% graduating within six years. Computer Science is the most popular major.
Location Ithaca, NY
Institution Type Private
Student Enrollment 24,027
The University of California in Los Angeles is a very large school with over 44,000 students. A public land-grant research university, it’s the second-oldest branch of the school system. Its motto is Fiat lux, or “Let there be Light.” Famous alumni have included Sean Astin, Francis Ford Coppola, Michael Morhaime, Jim Morrison, and Troy Aikman. It has an acceptance rate of 12%.
Location Los Angeles, CA
Institution Type Public
Student Enrollment 44,371

Interested in any of these schools? Check out College Raptor’s free match tool to see if they’re a good fit for you!


Colleges are ranked based on a combination of factors, including graduation rates, campus diversity, endowment per student, and other data as reported via the National Center for Education Statistics (NCES) for the most recently-available enrollment year. Some colleges may have been excluded from rankings based on certain criteria, including specialization and classification. Learn about our full methodology.

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