UChicago has 51 academic majors available to students in five divisions: Biological Sciences Collegiate Division, the Physical Sciences Collegiate Division, the Social Sciences Collegiate Division, the Humanities Collegiate Division, and the New Collegiate Division. They also offer 33 minors. Many students go towards Econometrics and Quantitative Economics, Mathematics, General, Biology/Biological Sciences, General, Computer Science, Political Science and Government, and General.

The university is well known for their 15 required general education courses, or Common Core. They also require students to be proficient in at least one foreign language. All core courses are limited to only seventeen students with a professor, allowing for small discussion classes. Students should note that undergraduate classes are considered to have demanding standards with a heavy workload.

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